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It is pointed out in the passage that the existence of plaques in the brain ----.
Researchers are a step closer to understanding how
Alzheimer's disease takes shape – literally. A sign of
Alzheimer's is the presence of protein aggregates in
the brain known as plaques. They are made up of
various lengths and conformations of the beta
amyloid protein. The proteins link end to end, forming
long, threadlike structures called fibrils. Now biologist
Roland Riek and his colleagues have constructed a
three-dimensional model of the fibrils based on their
own experiments and earlier data published by
others. Riek says the model will help investigators to
understand protein structure, which could lead to
better targeted drugs. For example, molecules could
be engineered to act as protein binding partners,
thus interfering with fibril formation. Such a sticky
molecule could also be used to diagnose the disease
early. The model work might lend insight to other
neurological disorders that involve fibril formation,
such as Parkinson's disease. Riek says his group will
extend the three-dimensional work to other variations
of the amyloid protein, because it undergoes many
conformational changes on its way to forming a fibril.
“We need to try to trap them in these intermediate
states”, he explains.