SORU: boş bırakılan yere parçanın anlam bütünlüğünü sağlamak için getirilebilecek cümleyi bulunuz
Opioid analgesics are very effective in controlling pain but have many side effects. ----. In addition, before a long-term use of opioid analgesics can be stopped, the dose must be gradually reduced to minimize the development of withdrawal symptoms.